1. Clinical Trials with BioGaia products. Data on file.
2. Prescribing statistics 2021. Data on file
3. Guarner F, Sanders ME, Eliakim, et al. World Gastroenterology Organisation (WGO) Global Guidelines. Probiotics and prebiotics, February 2017.
4. Reuterina® Drops Approved Package Insert, August 2009.
5. Reuterina Junior® Approved Package Insert, July 2010.
6. Reuterina Acute® Approved Package Insert, March 2010.
7. Reuterina Daily® Approved Package Insert, July 2010.
8. Reuterina® Vit D (drops) Approved Package Insert, August 2013.
9. Eom T-H, et al. The therapeutic effect of Lactobacillus reuteri in acute diarrhea in infants and toddlers. Korean J Ped 2005;48:986-989.
10. Weizman Z, et al. Effect of a probiotic infant formula on infections in child-care centers: Comparison of two probiotic agents. Pediatrics 2005;115:5-9.
11. Savino F, Pelle E, Palumeri E, et al. Lactobacillus reuteri (American Type Culture Collection Strain 55730) Versus Simethicone in the Treatment of Infantile Colic: A Prospective Randomized Study. Pediatrics 2007;119:e124.
12. Mi GL, Zhao L, Qiao DD, et al. Effectiveness of Lactobacillus reuteri in infantile colic and colicky induced maternal depression: a prospective single blind randomized trial. Antonie Van Leeuwenhoek 2015;107(154):1557-1553.
13. Chau K, et al. Probiotics for infantile colic: a randomized double-blind placebo-controlled trial investigating Lactobacillus reuteri DSM 17938. J Pediatr 2014;166:74-78.
14. Szajewska H, et al. Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: A randomized, double-blind, placebo-controlled trial. J Pediatr 2013;162:257-262.
15. Indrio F, et al. The effects of probiotics on feeding tolerance, bowel habits, and gastrointestinal motility in preterm newborns. J Pediatr 2008;152:801-806.
16. Indrio F, et al. Lactobacillus reuteri accelerates gastric emptying and improves regurgitation in infants. Eur J Clin Invest 2011;41:417-422.
17. Indrio F, et al. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation. A randomized clinical trial. JAMA Pediatr 2014;168:228-233.
18. Olgac MAB, et al. Comparison of probiotic and lactulose treatments in children with functional constipation and determination of the effects of constipation treatment on quality of life. Cocuk Sağlığı ve Hastalıkları Dergisi [Turkish Pediatric Journal] 2013;56: 1-7.
19. Coccorullo P, et al. Lactobacillus reuteri (DSM 17938) in infants with functional chronic constipation: a double-blind, randomized, placebo-controlled study. J Pediatrics 2010;157:598-602.
20. Romano C, et al. Lactobacillus reuteri in children with functional abdominal pain (FAP). J Paediatr Child Health 2014;50(10):E68-E71.
21. Jadresin O, et al. Lactobacillus reuteri DSM 17938 in the treatment of functional abdominal pain in children – RCT study. J Pediatr Gastroenterol Nutr 2017;64:925-929.
22. Ojetti V, laniro G, Tortora A, et al. Effect of Lactobacillus reuteri. supplementation in adults with chronic functional constipation: a randomised double-blind. placebo-controlled trial. J Gastrointestin Liver Dis 2014;23:387-391.
23. Cimperman L, Bayless G, Best K, et al. A randomized. Double-blind. Placebo-controlled pilot study of Lactobacillus reuteri ATCC 55730 for the prevention of antibiotic-associated diarrhoea in hospitalized adults. J Clin Gastroenterol 2011;45:785-789.
24. Gutierrez-Castrellon P, et al. Diarrhea in preschool children and Lactobacillus reuteri: a randomized controlled trial. Pediatrics 2014;133:4 e904-e909.
25. Agustina R, et al. Randomized trial of probiotics and calcium on diarrhea and respiratory tract infections in Indonesian children. Pediatrics 2012;129:e1155-e1164.
26. BioGaia. What are probiotics? Available from: https://www.biogaia.com/probiotic-health/what-are-probiotics/ [Accessed 12 January 2023].
27. Company Data on file. BioGaia. Free from claims. Master recipe.
28. BioGaia. Products. Storage. Available from:
https://www.biogaia.com/products/questionsanswers/#what-if-the-product-is-exposed-to-temperatures-of-30c-and-above [Accessed 12 January 2023].
29. BioGaia. Stomach pain in children. Available from: https://www.biogaia.com/health-areas/probiotic-baby-and-child-gut-health/functional-abdominal-pain-in-children/ [Accessed 15 January 2023].
30. BioGaia. Colic. Available from: https://www.biogaia.com/health-areas/probiotic-baby-and-child-gut-health/colic/ [Accessed 13 January 2023].
31. BioGaia. Children and infections. Available from: https://www.biogaia.com/health-areas/probiotic-baby-and-child-gut-health/kids-and-infections/ [Accessed 13 January 2023].
32. BioGaia. Functional Constipation in children. Available from: https://www.biogaia.com/health-areas/probiotic-baby-and-child-gut-health/functional-constipation-in-children/ [Accessed 1 January 2023].
33. BioGaia. Diarrhoea. Available from: https://www.biogaia.com/health-areas/probiotic-gut-health/diarrhoea/ [Accessed 13 January 2023].
34. BioGaia. Constipation. Available from: https://www.biogaia.com/health-areas/probiotic-gut-health/constipation/ [Accessed 13 January 2023].
35. BioGaia. Helicobacter pylori. Available from: https://www.biogaia.com/health-areas/probiotic-gut-health/helicobacter-pylori/ [Accessed 13 January 2023].
36. BioGaia. Regurgitation. Available from: https://www.biogaia.com/health-areas/probiotic-baby-and-child-gut-health/regurgitation/ [Accessed 13 January 2023].[‘[‘
37. BioGaia. The importance of gut bacteria. Available from: https://www.biogaia.com/probiotic-health/the-importance-of-gut-bacteria/ [Accessed 15 January 2023].
38. Petricevic L, Unger FM, Viernste H, et al. Randomized, double-blind, placebo-controlled study of oral lactobacilli to improve the vaginal flora of postmenopausal women. Eur J Obstet Gynecol 2008:141:54-57.
39. Beerepoot M, Geerlings S. Non-Antibiotic Prophylaxis for Urinary Tract Infections. Pathogens 2016;5(6): doi:10.3390/pathogens5020036.
40. Reid G, Charbonneau D, Erb J, et al. Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women. FEMS Immunol Med Microbiol 2003;35:131-134.
41. Reuterina femme® Approved Package Insert, August 2009.
42. BioGaia. Diarrhoea in children. Available from: https://www.biogaia.com/health-areas/probiotic-baby-and-child-gut-health/diarrhea-in-children/ [Accessed 15 January 2023].
43. BioGaia. What is L. reuteri? Available from: https://www.biogaia.com/probiotic-health/l-reuteri-strains/ [Accessed 15 January 2023].
44. BioGaia. Probiotic myths. Available from: https://www.biogaia.com/probiotic-health/what-are-probiotics/probiotic-myth/ [Accessed 15 January 2023].
45. Savino F, et al. Crying time and RORy/FOXP3 expression in Lactobacillus reuteri DSM 17938-treated infants with colic: A randomized trial. J Pediatr 2018;192:171-177.
46. Abrahamsson TR, Jakobsson T, Böttcher MF, et al. Probiotics in prevention of IgE-associated eczema: A double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol. 2007;119(5):1174-1180.
47. Ojetti V, Gigante G, Gabrielli M et al. The effect of oral supplementation with Lactobacillus reuteri or tilactase in lactose intolerant patients: randomized trial. Eur Rev Med Pharmacol Sci 2010 Mar;14(3):163-70.
48. Tubelius P, Stan V, Zachrisson A. Increasing workplace healthiness with the probiotic Lactobacillus reuteri: A randomised, double-blind placebo-controlled study. Environmental Health 2005;4:25.
49. Ostlund-Lagerstrom L, Kihlgren A, Repsilber D, et al. Probiotic administration among free-living older adults: a double-blinded, randomized, placebo-controlled clinical trial. Nutr J 2016;15:80.
50. Dumitru IM, Kugina S, Cosma L, et al. The effect of Lactobacillus reuteri therapy in intestinal disorders of various causes in HIV-infected patients. Infection 2009;5(2):18-21.
51. Gardiner GE, Heinemann C, Baroja ML, et al. Oral administration of the probiotic combination Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 for human intestinal applications. Int Dairy J 2002;12:191-196.
52. Anukam KC, Duru MU, Eze CC, et al. Oral use of probiotics as adjunctive therapy to fluconazole in the treatment of yeast vaginitis: A study of Nigerian Women in an outdoor clinic. Microbial Ecology in Health and Disease 2009;21:72-77.
53. Miraglia del Giudice M, Maiello N, Decimo F, et al. Airways allergic inflammation and Lactobacillus reuteri treatments in asthmatic children. Journal of Biological Regulators & Homeostatic Agents 2012;26(1S):35-40.
54. Wang Y, Xiaolu Li, Ting GE, et al. Probiotics for prevention and treatment of respiratory tract infections in children A systematic review and meta-analysis of randomized controlled trials. Medicine 2016;95(31):E509.
55. Lionetti E, Miniello VL, Castellaneta SP, et al. Lactobacillus reuteri therapy to reduce side-effects during anti-Helicobacter pylori treatment in children: a randomised placebo-controlled trial. Aliment Pharmacol Ther 2006;24:1461-1468.